For first-time use, thoroughly wash the bottle, tube, and cap with warm soapy water before use. Add lukewarm pre-boiled water into the bottle up to the FILL line. Add the contents of one FLO Sinus Care sachet into the FLO sinus wash bottle. Screw the cap firmly onto the bottle and shake until all powder has dissolved. Lean forward and insert the tip of the cap gently into one nostril. While breathing through your mouth, gently squeeze the bottle until the solution drains from the opposite nostril. Repeat on the other nostril. This product is packaged with a Consumer Information Leaflet to provide more detailed instructions.